Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

Chronic Eosinophilic Leukemia Presenting as Cardiac Failure

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Chronic eosinophilic leukemia (CEL) is a rare chronic myeloproliferative disorder characterized by sustained eosinophilia.Although the incidence of CEL is uncertain, it can be clinically devastating as it has a propensity to affect several important organ systems.This is of particular significance in Sub-Saharan Africa where helminthic infections PEACE are a more prevalent cause of eosinophilia.To the best of our knowledge, we present the first reported case of CEL complicated by cardiac disease in a Ghanaian.

He presented with a history of orthopnoea and dyspnoea on exertion, and examination revealed a pansystolic murmur over the mitral region and moderate splenomegaly.Good symptomatic control was achieved using hydroxyurea after Agitator Shaft Seal which haematologic and cytogenetic remission was achieved after 12 weeks on a tyrosine kinase inhibitor.Physicians working in low resource environments should exclude clonality in patients presenting with eosinophilia and end-organ damage.